Mikaila's paper on conformational signaling published

By carefully analyzing the results of single-molecule FRET experiments, Mikaila was able to uncover new features of the ligand-dependent conformational signaling in the E. coli aspartate receptor Tar. Her work, which now appears in PNAS, shows that collective geometry of the transmembrane helices is important for signaling, and also demonstrates the efficacy of single-molecule FRET in understanding conformational changes in membrane proteins.