MODEL MEMBRANE SYSTEMS

  TEM image of nanodiscs containing LHCII                

TEM image of nanodiscs containing LHCII

 

 

 

 

 

Membrane proteins are ubiquitous in biology; 30% of the genes in most genomes encode membrane proteins and 60% of drug targets are membrane proteins. However, they are a notoriously challenging class of proteins to study due to the difficulty of maintaining a physiologically-relevant environment while conducting experiments. We meet this challenge by constructing well-controlled model membrane-protein systems that mimic physiological environments. Membrane proteins are key to biological processes and, because they are so poorly understood, are often at the heart of unanswered questions.

 

J. Ogren, A. Tong, S. Gordon, A. Chenu, Y. Lu, R. Blankenship, J. Cao, G.S. Schlau-Cohen. "Impact of the lipid bilayer on energy transfer kinetics in the photosynthetic protein LH2." Chem Sci8, 3095 (2018).

Group Members: Ashley, Julianne, Minjung, Jesse, Shwetha, Olivia